Interactions between proteins and ligands control processes in living cells, both human and bacterial. Their description at a molecular level is essential to better understand the relationships between a tumor cell and its environment or between a pathogen and its host. We couple methods such as molecular biology, protein biochemistry with microbiology and mammalian cell biology to generate new findings in basic research and translate them into novel biotechnological and biomedical applications. The research of our group is focused on three complementary axes:
1-Design of novel proteins for diagnostic and therapeutic interventions
We have established Affitins as a class of affinity proteins much smaller and stable than monoclonal antibodies. By using Affitins, we design novel proteins for detecting, capturing and modulating activity of protein targets.
Across all our projects involving the use of Affitins, we also continuously improve their properties by using rational or combinatorial protein engineering approaches. For instance, we aim to enhance their biodisponibility.
3-Identification of targets
In a pathological context, we use classical biochemistry approaches or a combinatorial wide-genome approach we have developed to explore protein-ligand interactions. For example, we are seeking to better understand how a pathogen interacts with human cells.